Immunologic aspects of the nephrotic syndrome

The nephrotic syndrome of childhood: immunologic, clinical, and pathologic correlations.

Immunologic aspects of hypoplastic myelodysplastic syndrome.

The pathophysiology of myelodysplastic syndromes (MDS) is multiple, complex, and poorly understood. In some cases of MDS, especially those in which the bone marrow is hypocellular, there is increasing experimental and clinical indication that an immune-mediated damage to hematopoietic precursors and changes in the hematopoiesis-supporting microenvironment contribute to disease development. Incr...

New aspects of the treatment of nephrotic syndrome.

The nephrotic syndrome, caused by glomerulonephritis, diabetes mellitus, or amyloidosis, is still a therapeutic challenge. Newer therapeutic approaches may be sought in the fields of immunosuppression, nonspecific supportive measures, heparinoid administration, and removal of a supposed glomerular basement membrane toxic factor. In immunosuppression, the newer drugs now used in organ transplant...

Immunological aspects of nephrotic syndrome in northern Nigeria.

Immunological aspects of 40 northern Nigerian children with nephrotic syndrome of recent onset are reported. Eight our of 30 had hepatitis-associated antigen in their sera. Hypocomplementaemia was rare. Measurement of serum C3, C4, and ASOT was not of diagnostic value. Proteinuria selectivity index was poor in half of the patients, and appeared t o depend on the severity of the kidney lesion. A...

Multiple sclerosis: immunologic aspects.

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). Although the causes are not known, the pathogenesis likely involves complex relationships between autoimmunity, immunogenetics, immunologic deficiency and viral infection. The evidence for such interrelationships is discussed.